Mitochondrial Transplantation by Intra-Arterial Injection for Acute Kidney Injury
After 24 hours, estimated glomerular filtration rate and urine output were significantly increased while serum creatinine and blood urea nitrogen were significantly decreased in swine receiving mitochondria as compared to those receiving vehicle.
- Mitochondrial transplantation prevented I/R-induced damages to the renal tissue.•
- Mitochondrial transplantation enhanced and increased regenerative potential of renal cells after I/R injury.•
- Mitochondrial transplantation prevented I/R-induced apoptosis in renal cells.•
- Mitochondrial transplantation might be considered as a novel therapeutic strategy for treatment of AKI.
Am J Physiol Renal Physiol. 2020 Jul 20.
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 1866:8,2020